Entity Details

Primary name GRAB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10144
EntryNameGRAB_HUMAN
FullNameGranzyme B
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGZMB

GO terms

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GOName
GO:0001772 immunological synapse
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008236 serine-type peptidase activity
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019835 cytolysis
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043231 intracellular membrane-bounded organelle
GO:0044194 cytolytic granule
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0070269 pyroptosis
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytolytic granule
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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