Entity Details

Primary name ANDR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10275
EntryNameANDR_HUMAN
FullNameAndrogen receptor
TaxID9606
Evidenceevidence at protein level
Length920
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesAR

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001091 RNA polymerase II general transcription initiation factor binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0003073 regulation of systemic arterial blood pressure
GO:0003382 epithelial cell morphogenesis
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005496 steroid binding
GO:0005497 androgen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0019102 male somatic sex determination
GO:0019899 enzyme binding
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0033327 Leydig cell differentiation
GO:0035264 multicellular organism growth
GO:0042327 positive regulation of phosphorylation
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045597 positive regulation of cell differentiation
GO:0045720 negative regulation of integrin biosynthetic process
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0048638 regulation of developmental growth
GO:0048645 animal organ formation
GO:0048808 male genitalia morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051117 ATPase binding
GO:0060520 activation of prostate induction by androgen receptor signaling pathway
GO:0060571 morphogenesis of an epithelial fold
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060736 prostate gland growth
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
GO:0060749 mammary gland alveolus development
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0070974 POU domain binding
GO:0071383 cellular response to steroid hormone stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071394 cellular response to testosterone stimulus
GO:0072520 seminiferous tubule development
GO:1903076 regulation of protein localization to plasma membrane
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001103 Androgen receptorFamilyFamily
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00367 LevonorgestrelDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB00621 OxandroloneDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00648 MitotaneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00665 NilutamideDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00858 DrostanoloneDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB00984 Nandrolone phenpropionateDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01063 AcetophenazineDrugbanksmall molecule
DB01128 BicalutamideDrugbanksmall molecule
DB01185 FluoxymesteroneDrugbanksmall molecule
DB01395 DrospirenoneDrugbanksmall molecule
DB01406 DanazolDrugbanksmall molecule
DB01420 Testosterone propionateDrugbanksmall molecule
DB01428 OxybenzoneDrugbanksmall molecule
DB01481 1-TestosteroneDrugbanksmall molecule
DB01541 BoldenoneDrugbanksmall molecule
DB01564 CalusteroneDrugbanksmall molecule
DB01608 PericiazineDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02901 StanoloneDrugbanksmall molecule
DB02932 (R)-BicalutamideDrugbanksmall molecule
DB02998 MetriboloneDrugbanksmall molecule
DB04709 (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONEDrugbanksmall molecule
DB04839 Cyproterone acetateDrugbanksmall molecule
DB05234 LGD2941Drugbanksmall molecule
DB06133 DimethylcurcuminDrugbanksmall molecule
DB06412 OxymetholoneDrugbanksmall molecule
DB06710 MethyltestosteroneDrugbanksmall molecule
DB06713 NorelgestrominDrugbanksmall molecule
DB06718 StanozololDrugbanksmall molecule
DB06870 TetrahydrogestrinoneDrugbanksmall molecule
DB07039 (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamideDrugbanksmall molecule
DB07286 BMS-564929Drugbanksmall molecule
DB07419 S-23Drugbanksmall molecule
DB07421 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrileDrugbanksmall molecule
DB07422 (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamideDrugbanksmall molecule
DB07423 AndarineDrugbanksmall molecule
DB07454 (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDEDrugbanksmall molecule
DB07717 (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONEDrugbanksmall molecule
DB07769 S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDEDrugbanksmall molecule
DB08035 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINEDrugbanksmall molecule
DB08087 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILEDrugbanksmall molecule
DB08088 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrileDrugbanksmall molecule
DB08089 LGD-2226Drugbanksmall molecule
DB08461 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOLDrugbanksmall molecule
DB08604 TriclosanDrugbanksmall molecule
DB08804 Nandrolone decanoateDrugbanksmall molecule
DB08867 UlipristalDrugbanksmall molecule
DB08899 EnzalutamideDrugbanksmall molecule
DB09086 EugenolDrugbanksmall molecule
DB09123 DienogestDrugbanksmall molecule
DB09371 NorethynodrelDrugbanksmall molecule
DB09389 NorgestrelDrugbanksmall molecule
DB11064 HomosalateDrugbanksmall molecule
DB11219 EnzacameneDrugbanksmall molecule
DB11429 MiboleroneDrugbanksmall molecule
DB11447 PhenothiazineDrugbanksmall molecule
DB11619 GestrinoneDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB12941 DarolutamideDrugbanksmall molecule
DB13155 EsculinDrugbanksmall molecule
DB13934 LigandrolDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13951 Stanolone acetateDrugbanksmall molecule
DB14583 Segesterone acetateDrugbanksmall molecule
DB14639 Boldenone undecylenateDrugbanksmall molecule
DB15488 EchinacosideDrugbanksmall molecule
DB15647 KetodarolutamideDrugbanksmall molecule

Interactions

3 interactions