Entity Details

Primary name RARA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10276
EntryNameRARA_HUMAN
FullNameRetinoic acid receptor alpha
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesRARA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001972 retinoic acid binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009755 hormone-mediated signaling pathway
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030851 granulocyte differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0031490 chromatin DNA binding
GO:0032526 response to retinoic acid
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032991 protein-containing complex
GO:0043277 apoptotic cell clearance
GO:0043422 protein kinase B binding
GO:0044323 retinoic acid-responsive element binding
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048384 retinoic acid receptor signaling pathway
GO:0051018 protein kinase A binding
GO:0051099 positive regulation of binding
GO:0051393 alpha-actinin binding
GO:0071391 cellular response to estrogen stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003078 Retinoic acid receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00799 TazaroteneDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB00982 IsotretinoinDrugbanksmall molecule
DB04942 TamibaroteneDrugbanksmall molecule
DB05785 LGD-1550Drugbanksmall molecule
DB12808 TrifaroteneDrugbanksmall molecule