Entity Details

Primary name THIO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10599
EntryNameTHIO_HUMAN
FullNameThioredoxin
TaxID9606
Evidenceevidence at protein level
Length105
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTXN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003723 RNA binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006662 glycerol ether metabolic process
GO:0009314 response to radiation
GO:0015035 protein-disulfide reductase activity
GO:0032148 activation of protein kinase B activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043388 positive regulation of DNA binding
GO:0045454 cell redox homeostasis
GO:0046826 negative regulation of protein export from nucleus
GO:0047134 protein-disulfide reductase (NAD(P)) activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:0071731 response to nitric oxide
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR005746 ThioredoxinFamilyFamily
IPR013766 Thioredoxin domainDomainDomain
IPR017937 Thioredoxin, conserved siteSiteConserved site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
THIO_HUMANTXNIP_MOUSEBioGRID10843682 16766796 details
THIO_HUMANMELK_MOUSEBioGRID23747528 details