Entity Details

Primary name KAP0_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10644
EntryNameKAP0_HUMAN
FullNamecAMP-dependent protein kinase type I-alpha regulatory subunit
TaxID9606
Evidenceevidence at protein level
Length381
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPRKAR1A

GO terms

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GOName
GO:0001707 mesoderm formation
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005952 cAMP-dependent protein kinase complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007143 female meiotic nuclear division
GO:0007268 chemical synaptic transmission
GO:0007596 blood coagulation
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0010738 regulation of protein kinase A signaling
GO:0016020 membrane
GO:0019904 protein domain specific binding
GO:0030552 cAMP binding
GO:0031588 nucleotide-activated protein kinase complex
GO:0031594 neuromuscular junction
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0034199 activation of protein kinase A activity
GO:0034236 protein kinase A catalytic subunit binding
GO:0035556 intracellular signal transduction
GO:0043949 regulation of cAMP-mediated signaling
GO:0044853 plasma membrane raft
GO:0045214 sarcomere organization
GO:0045835 negative regulation of meiotic nuclear division
GO:0046007 negative regulation of activated T cell proliferation
GO:0060038 cardiac muscle cell proliferation
GO:0071377 cellular response to glucagon stimulus
GO:0097224 sperm connecting piece
GO:0097546 ciliary base
GO:0098978 glutamatergic synapse
GO:2000480 negative regulation of cAMP-dependent protein kinase activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domainDomainDomain
IPR012198 cAMP-dependent protein kinase regulatory subunitFamilyFamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01790 (Rp)-cAMPSDrugbanksmall molecule
DB02315 Cyclic GMPDrugbanksmall molecule
DB02527 Cyclic adenosine monophosphateDrugbanksmall molecule
DB05798 GEM-231Drugbankbiotech

Interactions

4 interactions