Entity Details

Primary name THA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10827
EntryNameTHA_HUMAN
FullNameThyroid hormone receptor alpha
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTHRA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002154 thyroid hormone mediated signaling pathway
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0017025 TBP-class protein binding
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030878 thyroid gland development
GO:0031490 chromatin DNA binding
GO:0033032 regulation of myeloid cell apoptotic process
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050994 regulation of lipid catabolic process
GO:0060509 type I pneumocyte differentiation
GO:0070324 thyroid hormone binding
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000143 negative regulation of DNA-templated transcription, initiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB03176 KB-141Drugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05035 EprotiromeDrugbanksmall molecule
DB05235 NRP409Drugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
THA_HUMANHDAC2_MOUSEBioGRID10508171 details
THA_HUMANNR0B2_MOUSEBioGRID8650544 details