Entity Details

Primary name THB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10828
EntryNameTHB_HUMAN
FullNameThyroid hormone receptor beta
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTHRB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002154 thyroid hormone mediated signaling pathway
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007605 sensory perception of sound
GO:0007621 negative regulation of female receptivity
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0008270 zinc ion binding
GO:0009755 hormone-mediated signaling pathway
GO:0016604 nuclear body
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0031490 chromatin DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046549 retinal cone cell development
GO:0060509 type I pneumocyte differentiation
GO:0070324 thyroid hormone binding
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097474 retinal cone cell apoptotic process
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB02106 [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic AcidDrugbanksmall molecule
DB03176 KB-141Drugbanksmall molecule
DB03181 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-DioneDrugbanksmall molecule
DB03604 TiratricolDrugbanksmall molecule
DB03788 GC-24Drugbanksmall molecule
DB05035 EprotiromeDrugbanksmall molecule
DB05192 MB07811Drugbanksmall molecule
DB07425 SobetiromeDrugbanksmall molecule
DB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONEDrugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
THB_HUMANNCOR1_MOUSEIntAct12904255 details
THB_HUMANHDAC2_MOUSEBioGRID10508171 details