Entity Details

Primary name CLUS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10909
EntryNameCLUS_HUMAN
FullNameClusterin
TaxID9606
Evidenceevidence at protein level
Length449
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCLU

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0002434 immune complex clearance
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0009615 response to virus
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0017038 protein import
GO:0019730 antimicrobial humoral response
GO:0030449 regulation of complement activation
GO:0031093 platelet alpha granule lumen
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034366 spherical high-density lipoprotein particle
GO:0042127 regulation of cell population proliferation
GO:0042583 chromaffin granule
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0048156 tau protein binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0060548 negative regulation of cell death
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0061741 obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
GO:0099020 perinuclear endoplasmic reticulum lumen
GO:1900221 regulation of amyloid-beta clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of amyloid-beta formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of amyloid-beta formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1905892 negative regulation of cellular response to thapsigargin
GO:1905895 negative regulation of cellular response to tunicamycin
GO:1905907 negative regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Microsome
Mitochondrion
Mitochondrion membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000753 Clusterin-likeFamilyFamily
IPR016014 Clusterin, N-terminalDomainDomain
IPR016015 Clusterin, C-terminalDomainDomain
IPR016016 ClusterinFamilyFamily
IPR033986 Clusterin, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CLUS_HUMANLEP_MOUSEBioGRID12824284 details