Entity Details

Primary name IRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10914
EntryNameIRF1_HUMAN
FullNameInterferon regulatory factor 1
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesIRF1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR017431 Interferon regulatory factor-1/2FamilyFamily
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR031215 Interferon regulatory factor 1FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IRF1_HUMANTBK1_MOUSEBioGRID23746807 details