Entity Details

Primary name BCR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11274
EntryNameBCR_HUMAN
FullNameBreakpoint cluster region protein
TaxID9606
Evidenceevidence at protein level
Length1271
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesBCR

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0030216 keratinocyte differentiation
GO:0030424 axon
GO:0032991 protein-containing complex
GO:0035023 regulation of Rho protein signal transduction
GO:0043197 dendritic spine
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0050804 modulation of chemical synaptic transmission
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070062 extracellular exosome
GO:0090630 activation of GTPase activity
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR015123 Bcr-Abl oncoprotein oligomerisationDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamilyFamilyHomologous superfamily
IPR037769 Abr/BcrFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
BCR_HUMANNUMB_MOUSEBioGRID, IntAct23211419 details
BCR_HUMANSH2D5_MOUSEIntAct25331951 details