Entity Details

Primary name FGFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11362
EntryNameFGFR1_HUMAN
FullNameFibroblast growth factor receptor 1
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001501 skeletal system development
GO:0001764 neuron migration
GO:0001837 epithelial to mesenchymal transition
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031410 cytoplasmic vesicle
GO:0033674 positive regulation of kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043009 chordate embryonic development
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048705 skeletal system morphogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0090722 receptor-receptor interaction
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR028174 Fibroblast growth factor receptor 1, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00039 PaliferminDrugbankbiotech
DB00398 SorafenibDrugbanksmall molecule
DB01109 HeparinDrugbanksmall molecule
DB02058 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinoneDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridineDrugbanksmall molecule
DB07840 (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanolDrugbanksmall molecule
DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONEDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule