Entity Details

Primary name TOP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11387
EntryNameTOP1_HUMAN
FullNameDNA topoisomerase 1
TaxID9606
Evidenceevidence at protein level
Length765
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTOP1

GO terms

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GOName
GO:0000932 P-body
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0007623 circadian rhythm
GO:0012501 programmed cell death
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0032922 circadian regulation of gene expression
GO:0032993 protein-DNA complex
GO:0040016 embryonic cleavage
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0097100 supercoiled DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001631 DNA topoisomerase IFamilyFamily
IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-typeDomainDomain
IPR011010 DNA breaking-rejoining enzyme, catalytic coreFamilyHomologous superfamily
IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2FamilyHomologous superfamily
IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1FamilyHomologous superfamily
IPR013499 DNA topoisomerase I, eukaryotic-typeDomainDomain
IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-typeDomainDomain
IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typeFamilyHomologous superfamily
IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomainFamilyHomologous superfamily
IPR018521 DNA topoisomerase I, active siteSiteActive site
IPR025834 Topoisomerase I C-terminal domainDomainDomain
IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00762 IrinotecanDrugbanksmall molecule
DB01030 TopotecanDrugbanksmall molecule
DB04690 CamptothecinDrugbanksmall molecule
DB04882 EdotecarinDrugbanksmall molecule
DB04967 LucanthoneDrugbanksmall molecule
DB05129 ElsamitrucinDrugbanksmall molecule
DB05482 7-ethyl-10-hydroxycamptothecinDrugbanksmall molecule
DB05630 Sodium stibogluconateDrugbanksmall molecule
DB05806 CositecanDrugbanksmall molecule
DB06069 XMT-1001Drugbanksmall molecule
DB06159 RubitecanDrugbanksmall molecule
DB07354 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUMDrugbanksmall molecule
DB08159 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATEDrugbanksmall molecule
DB11254 HexylresorcinolDrugbanksmall molecule
DB12893 Sacituzumab govitecanDrugbankbiotech
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

0 interactions

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