Entity Details

Primary name TOP2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11388
EntryNameTOP2A_HUMAN
FullNameDNA topoisomerase 2-alpha
TaxID9606
Evidenceevidence at protein level
Length1531
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTOP2A

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008301 DNA binding, bending
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0019899 enzyme binding
GO:0030263 apoptotic chromosome condensation
GO:0032991 protein-containing complex
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048511 rhythmic process
GO:1905463 negative regulation of DNA duplex unwinding
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001241 DNA topoisomerase, type IIAFamilyFamily
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminalDomainDomain
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR006171 TOPRIM domainDomainDomain
IPR012542 DTHCTDomainDomain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2DomainDomain
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaFamilyHomologous superfamily
IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminalFamilyHomologous superfamily
IPR013760 DNA topoisomerase, type IIA-like domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR018522 DNA topoisomerase, type IIA, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR031660 C-terminal associated domain of TOPRIMDomainDomain
IPR034157 DNA topoisomerase 2, TOPRIM domainDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00218 MoxifloxacinDrugbanksmall molecule
DB00276 AmsacrineDrugbanksmall molecule
DB00380 DexrazoxaneDrugbanksmall molecule
DB00385 ValrubicinDrugbanksmall molecule
DB00444 TeniposideDrugbanksmall molecule
DB00445 EpirubicinDrugbanksmall molecule
DB00467 EnoxacinDrugbanksmall molecule
DB00487 PefloxacinDrugbanksmall molecule
DB00537 CiprofloxacinDrugbanksmall molecule
DB00685 TrovafloxacinDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB00978 LomefloxacinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01059 NorfloxacinDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01177 IdarubicinDrugbanksmall molecule
DB01179 PodofiloxDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01208 SparfloxacinDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB04576 FleroxacinDrugbanksmall molecule
DB04967 LucanthoneDrugbanksmall molecule
DB04975 BanoxantroneDrugbanksmall molecule
DB04978 SP1049CDrugbanksmall molecule
DB05022 AmonafideDrugbanksmall molecule
DB05129 ElsamitrucinDrugbanksmall molecule
DB05706 13-deoxydoxorubicinDrugbanksmall molecule
DB05920 RTA 744Drugbanksmall molecule
DB06013 AldoxorubicinDrugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB06263 AmrubicinDrugbanksmall molecule
DB06362 BecatecarinDrugbanksmall molecule
DB06420 AnnamycinDrugbanksmall molecule
DB06421 DeclopramideDrugbanksmall molecule
DB09047 FinafloxacinDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink