Entity Details

Primary name VDR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11473
EntryNameVDR_HUMAN
FullNameVitamin D3 receptor
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesVDR

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000902 cell morphogenesis
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity
GO:0030154 cell differentiation
GO:0038183 bile acid signaling pathway
GO:0038186 lithocholic acid receptor activity
GO:0042359 vitamin D metabolic process
GO:0043235 receptor complex
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046697 decidualization
GO:0046965 retinoid X receptor binding
GO:0060558 regulation of calcidiol 1-monooxygenase activity
GO:0070561 vitamin D receptor signaling pathway
GO:0090575 RNA polymerase II transcription regulator complex
GO:1902098 calcitriol binding
GO:1902121 lithocholic acid binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000324 Vitamin D receptorFamilyFamily
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR042153 VDR, DNA-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00136 CalcitriolDrugbanksmall molecule
DB00146 CalcifediolDrugbanksmall molecule
DB00153 ErgocalciferolDrugbanksmall molecule
DB00169 CholecalciferolDrugbanksmall molecule
DB00910 ParicalcitolDrugbanksmall molecule
DB01070 DihydrotachysterolDrugbanksmall molecule
DB01436 AlfacalcidolDrugbanksmall molecule
DB02300 CalcipotriolDrugbanksmall molecule
DB03451 LexacalcitolDrugbanksmall molecule
DB04258 SeocalcitolDrugbanksmall molecule
DB04540 CholesterolDrugbanksmall molecule
DB04796 InecalcitolDrugbanksmall molecule
DB04891 BecocalcidiolDrugbanksmall molecule
DB05024 CTA018Drugbanksmall molecule
DB05295 EldecalcitolDrugbanksmall molecule
DB06194 ElocalcitolDrugbanksmall molecule
DB06410 DoxercalciferolDrugbanksmall molecule
DB07530 (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolDrugbanksmall molecule
DB08742 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)Drugbanksmall molecule
DB11094 Vitamin DDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
VDR_HUMANNCOA2_MOUSEBioGRID11514567 details
VDR_HUMANRXRA_MOUSEIntAct27728806 details