Entity Details

Primary name DMD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11532
EntryNameDMD_HUMAN
FullNameDystrophin
TaxID9606
Evidenceevidence at protein level
Length3685
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesDMD

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0007517 muscle organ development
GO:0008270 zinc ion binding
GO:0008307 structural constituent of muscle
GO:0009986 cell surface
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010976 positive regulation of neuron projection development
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014819 regulation of skeletal muscle contraction
GO:0016010 dystrophin-associated glycoprotein complex
GO:0016013 syntrophin complex
GO:0017022 myosin binding
GO:0017166 vinculin binding
GO:0030018 Z disc
GO:0030049 muscle filament sliding
GO:0030055 cell-substrate junction
GO:0030175 filopodium
GO:0031527 filopodium membrane
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0034622 cellular protein-containing complex assembly
GO:0035633 maintenance of blood-brain barrier
GO:0035994 response to muscle stretch
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0043043 peptide biosynthetic process
GO:0044306 neuron projection terminus
GO:0044458 motile cilium assembly
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045666 positive regulation of neuron differentiation
GO:0046716 muscle cell cellular homeostasis
GO:0050998 nitric-oxide synthase binding
GO:0060048 cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0086001 cardiac muscle cell action potential
GO:0090287 regulation of cellular response to growth factor stimulus
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR001202 WW domainDomainDomain
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015153 EF-hand domain, type 1DomainDomain
IPR015154 EF-hand domain, type 2DomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR035436 Dystrophin/utrophinFamilyFamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15593 GolodirsenDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DMD_HUMANDTNB_MOUSEIntAct14600269 details
DMD_HUMANNAC1_MOUSEbhf-ucl, BioGRID28755400 details