Entity Details

Primary name CDK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11802
EntryNameCDK4_HUMAN
FullNameCyclin-dependent kinase 4
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesCDK4

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0030851 granulocyte differentiation
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB02733 PurvalanolDrugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB09073 PalbociclibDrugbanksmall molecule
DB11730 RibociclibDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions