Entity Details

Primary name PCNA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12004
EntryNamePCNA_HUMAN
FullNameProliferating cell nuclear antigen
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesPCNA

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0005652 nuclear lamina
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0016032 viral process
GO:0030331 estrogen receptor binding
GO:0030855 epithelial cell differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0042769 DNA damage response, detection of DNA damage
GO:0042802 identical protein binding
GO:0043596 nuclear replication fork
GO:0044849 estrous cycle
GO:0070182 DNA polymerase binding
GO:0070557 PCNA-p21 complex
GO:1902990 mitotic telomere maintenance via semi-conservative replication
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005813 centrosome
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0019899 enzyme binding
GO:0030894 replisome
GO:0032139 dinucleotide insertion or deletion binding
GO:0032355 response to estradiol
GO:0032405 MutLalpha complex binding
GO:0035035 histone acetyltransferase binding
GO:0045739 positive regulation of DNA repair
GO:0046686 response to cadmium ion
GO:0070301 cellular response to hydrogen peroxide
GO:0071466 cellular response to xenobiotic stimulus
GO:0097421 liver regeneration
GO:0000785 chromatin
GO:0007507 heart development
GO:0016604 nuclear body
GO:0031297 replication fork processing
GO:0032077 positive regulation of deoxyribonuclease activity
GO:0043626 PCNA complex
GO:0044877 protein-containing complex binding
GO:0070062 extracellular exosome
GO:0071548 response to dexamethasone
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0006272 leading strand elongation
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006298 mismatch repair
GO:0008022 protein C-terminus binding
GO:0016567 protein ubiquitination
GO:0019985 translesion synthesis
GO:0030337 DNA polymerase processivity factor activity
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034644 cellular response to UV
GO:0042276 error-prone translesion synthesis
GO:0045740 positive regulation of DNA replication
GO:0070987 error-free translesion synthesis
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
GO:1902065 response to L-glutamate

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000730 Proliferating cell nuclear antigen, PCNAFamilyFamily
IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminalDomainDomain
IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminalDomainDomain
IPR022659 Proliferating cell nuclear antigen, PCNA, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule