Entity Details

Primary name APOE_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP08226
EntryNameAPOE_MOUSE
FullNameApolipoprotein E
TaxID10090
Evidenceevidence at protein level
Length311
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesApoe

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0005102 signaling receptor binding
GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0006979 response to oxidative stress
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007568 aging
GO:0007616 long-term memory
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008289 lipid binding
GO:0009986 cell surface
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010544 negative regulation of platelet activation
GO:0010596 negative regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010873 positive regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0010877 lipid transport involved in lipid storage
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0015909 long-chain fatty acid transport
GO:0016209 antioxidant activity
GO:0017038 protein import
GO:0019068 virion assembly
GO:0019934 cGMP-mediated signaling
GO:0030195 negative regulation of blood coagulation
GO:0030425 dendrite
GO:0031012 extracellular matrix
GO:0031175 neuron projection development
GO:0031232 extrinsic component of external side of plasma membrane
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0035641 locomotory exploration behavior
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0042982 amyloid precursor protein metabolic process
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043254 regulation of protein-containing complex assembly
GO:0043395 heparan sulfate proteoglycan binding
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043691 reverse cholesterol transport
GO:0044794 positive regulation by host of viral process
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045202 synapse
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045773 positive regulation of axon extension
GO:0045807 positive regulation of endocytosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046848 hydroxyapatite binding
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046911 metal chelating activity
GO:0046983 protein dimerization activity
GO:0048156 tau protein binding
GO:0048844 artery morphogenesis
GO:0050709 negative regulation of protein secretion
GO:0050728 negative regulation of inflammatory response
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050807 regulation of synapse organization
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051246 regulation of protein metabolic process
GO:0051651 maintenance of location in cell
GO:0055088 lipid homeostasis
GO:0055089 fatty acid homeostasis
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060999 positive regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061771 response to caloric restriction
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0070328 triglyceride homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071813 lipoprotein particle binding
GO:0071830 triglyceride-rich lipoprotein particle clearance
GO:0071831 intermediate-density lipoprotein particle clearance
GO:0072359 circulatory system development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090181 regulation of cholesterol metabolic process
GO:0090207 regulation of triglyceride metabolic process
GO:0090209 negative regulation of triglyceride metabolic process
GO:0090370 negative regulation of cholesterol efflux
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0098978 glutamatergic synapse
GO:0120020 cholesterol transfer activity
GO:1900221 regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901627 negative regulation of postsynaptic membrane organization
GO:1901631 positive regulation of presynaptic membrane organization
GO:1902004 positive regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902947 regulation of tau-protein kinase activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902952 positive regulation of dendritic spine maintenance
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1902999 negative regulation of phospholipid efflux
GO:1903001 negative regulation of lipid transport across blood-brain barrier
GO:1903002 positive regulation of lipid transport across blood-brain barrier
GO:1905855 positive regulation of heparan sulfate binding
GO:1905860 positive regulation of heparan sulfate proteoglycan binding
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus
GO:1905906 regulation of amyloid fibril formation
GO:1905907 negative regulation of amyloid fibril formation
GO:1990777 lipoprotein particle
GO:2000822 regulation of behavioral fear response

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000074 Apolipoprotein A/EFamilyFamily

Diseases

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Interactions

5 interactions