Entity Details

Primary name IMDH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12268
EntryNameIMDH2_HUMAN
FullNameInosine-5'-monophosphate dehydrogenase 2
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesIMPDH2

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003938 IMP dehydrogenase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
GO:0007623 circadian rhythm
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000644 CBS domainDomainDomain
IPR001093 IMP dehydrogenase/GMP reductaseDomainDomain
IPR005990 Inosine-5'-monophosphate dehydrogenaseFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR015875 IMP dehydrogenase / GMP reductase, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00811 RibavirinDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB01024 Mycophenolic acidDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB03070 Selenazole-4-carboxyamide-adenine dinucleotideDrugbanksmall molecule
DB03948 6-Chloropurine Riboside, 5'-MonophosphateDrugbanksmall molecule
DB04566 Inosinic AcidDrugbanksmall molecule
DB06103 VX-148Drugbanksmall molecule

Interactions

0 interactions

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