Entity Details

Primary name ACTN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12814
EntryNameACTN1_HUMAN
FullNameAlpha-actinin-1
TaxID9606
Evidenceevidence at protein level
Length892
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesACTN1

GO terms

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GOName
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0002576 platelet degranulation
GO:0003725 double-stranded RNA binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005911 cell-cell junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0007015 actin filament organization
GO:0017166 vinculin binding
GO:0030018 Z disc
GO:0030220 platelet formation
GO:0030374 nuclear receptor coactivator activity
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0036344 platelet morphogenesis
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0042995 cell projection
GO:0044325 transmembrane transporter binding
GO:0048041 focal adhesion assembly
GO:0051015 actin filament binding
GO:0051017 actin filament bundle assembly
GO:0051271 negative regulation of cellular component movement
GO:0051639 actin filament network formation
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse
GO:0099186 structural constituent of postsynapse

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06773 Human calcitoninDrugbankbiotech
DB09130 CopperDrugbanksmall molecule

Interactions

3 interactions