Entity Details

Primary name SRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12931
EntryNameSRC_HUMAN
FullNameProto-oncogene tyrosine-protein kinase Src
TaxID9606
Evidenceevidence at protein level
Length536
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesSRC

GO terms

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GOName
GO:0001545 primary ovarian follicle growth
GO:0001819 positive regulation of cytokine production
GO:0002102 podosome
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005102 signaling receptor binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0010447 response to acidic pH
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010907 positive regulation of glucose metabolic process
GO:0010954 positive regulation of protein processing
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016004 phospholipase activator activity
GO:0016032 viral process
GO:0016236 macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0020037 heme binding
GO:0022407 regulation of cell-cell adhesion
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030331 estrogen receptor binding
GO:0030900 forebrain development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031954 positive regulation of protein autophosphorylation
GO:0032148 activation of protein kinase B activity
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033625 positive regulation of integrin activation
GO:0034332 adherens junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035306 positive regulation of dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035635 entry of bacterium into host cell
GO:0036035 osteoclast development
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0042169 SH2 domain binding
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043149 stress fiber assembly
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043274 phospholipase binding
GO:0043393 regulation of protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 transmembrane transporter binding
GO:0045056 transcytosis
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045124 regulation of bone resorption
GO:0045296 cadherin binding
GO:0045453 bone resorption
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050847 progesterone receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051117 ATPase binding
GO:0051219 phosphoprotein binding
GO:0051222 positive regulation of protein transport
GO:0051385 response to mineralocorticoid
GO:0051602 response to electrical stimulus
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051974 negative regulation of telomerase activity
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060576 intestinal epithelial cell development
GO:0070062 extracellular exosome
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0070700 BMP receptor binding
GO:0070851 growth factor receptor binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071253 connexin binding
GO:0071375 cellular response to peptide hormone stimulus
GO:0071393 cellular response to progesterone stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071498 cellular response to fluid shear stress
GO:0071803 positive regulation of podosome assembly
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0086098 angiotensin-activated signaling pathway involved in heart process
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097110 scaffold protein binding
GO:0098609 cell-cell adhesion
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:1900182 positive regulation of protein localization to nucleus
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000386 positive regulation of ovarian follicle development
GO:2000394 positive regulation of lamellipodium morphogenesis
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2000641 regulation of early endosome to late endosome transport
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Mitochondrion inner membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB01678 RU84687Drugbanksmall molecule
DB01866 RU79256Drugbanksmall molecule
DB01893 N6-Benzyl Adenosine-5'-DiphosphateDrugbanksmall molecule
DB01908 RU85493Drugbanksmall molecule
DB01947 RU78262Drugbanksmall molecule
DB01962 PhosphonotyrosineDrugbanksmall molecule
DB02175 Malonic acidDrugbanksmall molecule
DB02336 RU83876Drugbanksmall molecule
DB02432 RU90395Drugbanksmall molecule
DB02762 RU79072Drugbanksmall molecule
DB02908 RU78783Drugbanksmall molecule
DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB03078 PASBNDrugbanksmall molecule
DB03104 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acidDrugbanksmall molecule
DB03114 PAS219Drugbanksmall molecule
DB03217 DPI59Drugbanksmall molecule
DB03268 RU82197Drugbanksmall molecule
DB03298 PhenylphosphateDrugbanksmall molecule
DB03306 RU78300Drugbanksmall molecule
DB03525 RU79073Drugbanksmall molecule
DB03591 RU82209Drugbanksmall molecule
DB03628 ISO24Drugbanksmall molecule
DB03712 RU85053Drugbanksmall molecule
DB03828 RU78299Drugbanksmall molecule
DB03902 Oxalic AcidDrugbanksmall molecule
DB04080 RU78191Drugbanksmall molecule
DB04272 Citric acidDrugbanksmall molecule
DB04495 Paratoulene phosphateDrugbanksmall molecule
DB04739 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDEDrugbanksmall molecule
DB04751 Purvalanol ADrugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB06882 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylureaDrugbanksmall molecule
DB06883 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylureaDrugbanksmall molecule
DB07335 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLDrugbanksmall molecule
DB07662 PD-168393Drugbanksmall molecule
DB07966 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrileDrugbanksmall molecule
DB08052 PP-121Drugbanksmall molecule
DB08053 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineDrugbanksmall molecule
DB08054 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineDrugbanksmall molecule
DB08192 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINEDrugbanksmall molecule
DB08462 N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDEDrugbanksmall molecule
DB08564 (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamideDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule