Entity Details

Primary name IL6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP08505
EntryNameIL6_MOUSE
FullNameInterleukin-6
TaxID10090
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesIl6

GO terms

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GOName
GO:0001781 neutrophil apoptotic process
GO:0001878 response to yeast
GO:0002262 myeloid cell homeostasis
GO:0002314 germinal center B cell differentiation
GO:0002384 hepatic immune response
GO:0002639 positive regulation of immunoglobulin production
GO:0002675 positive regulation of acute inflammatory response
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005896 interleukin-6 receptor complex
GO:0006469 negative regulation of protein kinase activity
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007568 aging
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0009897 external side of plasma membrane
GO:0010467 gene expression
GO:0010573 vascular endothelial growth factor production
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0014015 positive regulation of gliogenesis
GO:0014823 response to activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031000 response to caffeine
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0031294 lymphocyte costimulation
GO:0031669 cellular response to nutrient levels
GO:0032682 negative regulation of chemokine production
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032745 positive regulation of interleukin-21 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042060 wound healing
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042127 regulation of cell population proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200 response to amino acid
GO:0043410 positive regulation of MAPK cascade
GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045454 cell redox homeostasis
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045727 positive regulation of translation
GO:0045740 positive regulation of DNA replication
GO:0045779 negative regulation of bone resorption
GO:0045837 negative regulation of membrane potential
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046677 response to antibiotic
GO:0046716 muscle cell cellular homeostasis
GO:0046849 bone remodeling
GO:0046888 negative regulation of hormone secretion
GO:0048635 negative regulation of muscle organ development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050796 regulation of insulin secretion
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0051602 response to electrical stimulus
GO:0051607 defense response to virus
GO:0051897 positive regulation of protein kinase B signaling
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060252 positive regulation of glial cell proliferation
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0061470 T follicular helper cell differentiation
GO:0070091 glucagon secretion
GO:0070092 regulation of glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071392 cellular response to estradiol stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0072540 T-helper 17 cell lineage commitment
GO:0072574 hepatocyte proliferation
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0097421 liver regeneration
GO:0098586 cellular response to virus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904894 positive regulation of receptor signaling pathway via STAT
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1990646 cellular response to prolactin
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:2000635 negative regulation of primary miRNA processing
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR003574 Interleukin-6FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR030473 Interleukin-6/GCSF/MGF, conserved siteSiteConserved site
IPR030474 Interleukin-6/GCSF/MGFFamilyFamily

Diseases

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Interactions

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