Entity Details

Primary name CFTR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13569
EntryNameCFTR_HUMAN
FullNameCystic fibrosis transmembrane conductance regulator
TaxID9606
Evidenceevidence at protein level
Length1480
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesCFTR

GO terms

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GOName
GO:0005254 chloride channel activity
GO:0005260 intracellularly ATP-gated chloride channel activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006695 cholesterol biosynthetic process
GO:0006904 vesicle docking involved in exocytosis
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015701 bicarbonate transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016579 protein deubiquitination
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0019869 chloride channel inhibitor activity
GO:0019899 enzyme binding
GO:0030165 PDZ domain binding
GO:0030301 cholesterol transport
GO:0030660 Golgi-associated vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0032991 protein-containing complex
GO:0034707 chloride channel complex
GO:0034976 response to endoplasmic reticulum stress
GO:0035377 transepithelial water transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035973 aggrephagy
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0045921 positive regulation of exocytosis
GO:0048240 sperm capacitation
GO:0050891 multicellular organismal water homeostasis
GO:0051087 chaperone binding
GO:0051454 intracellular pH elevation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0061024 membrane organization
GO:0071320 cellular response to cAMP
GO:0106138 Sec61 translocon complex binding
GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity
GO:1902476 chloride transmembrane transport
GO:1902943 positive regulation of voltage-gated chloride channel activity
GO:1904322 cellular response to forskolin

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Early endosome membrane
Endoplasmic reticulum membrane
Nucleus
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR009147 Cystic fibrosis transmembrane conductance regulatorFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR025837 CFTR regulator domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB02587 ColforsinDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB04941 CrofelemerDrugbanksmall molecule
DB06266 LonidamineDrugbanksmall molecule
DB08820 IvacaftorDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09280 LumacaftorDrugbanksmall molecule
DB11712 TezacaftorDrugbanksmall molecule
DB15444 ElexacaftorDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
CFTR_HUMANNHRF3_MOUSEBioGRID, MINT11051556 details
CFTR_HUMANCFTR_MOUSEDIP17660831 details
CFTR_HUMANNHRF1_MOUSEBioGRID, MINT17110338 9613608 details