Entity Details

Primary name EF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13639
EntryNameEF2_HUMAN
FullNameElongation factor 2
TaxID9606
Evidenceevidence at protein level
Length858
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesEEF2

GO terms

Show/Hide Table
GOName
GO:0002039 p53 binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002931 response to ischemia
GO:0003009 skeletal muscle contraction
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006414 translational elongation
GO:0007568 aging
GO:0008097 5S rRNA binding
GO:0014009 glial cell proliferation
GO:0016020 membrane
GO:0016235 aggresome
GO:0019901 protein kinase binding
GO:0032355 response to estradiol
GO:0034774 secretory granule lumen
GO:0034976 response to endoplasmic reticulum stress
GO:0035914 skeletal muscle cell differentiation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042788 polysomal ribosome
GO:0043022 ribosome binding
GO:0043312 neutrophil degranulation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045296 cadherin binding
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0051015 actin filament binding
GO:0051593 response to folic acid
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:1990904 ribonucleoprotein complex
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000640 Elongation factor EFG, domain V-likeDomainDomain
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR005225 Small GTP-binding protein domainDomainDomain
IPR005517 Translation elongation factor EFG/EF2, domain IVDomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site
IPR035647 EF-G domain III/V-likeFamilyHomologous superfamily
IPR041095 Elongation Factor G, domain IIDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02059 Adenosine-5-DiphosphoriboseDrugbanksmall molecule
DB03223 DiphthamideDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB12688 Moxetumomab PasudotoxDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
EF2_HUMANAKT2_MOUSEIntAct23823123 details
EF2_HUMANMK13_MOUSEBioGRID19135240 details