Entity Details

Primary name MIF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14174
EntryNameMIF_HUMAN
FullNameMacrophage migration inhibitory factor
TaxID9606
Evidenceevidence at protein level
Length115
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesMIF

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0001819 positive regulation of cytokine production
GO:0004167 dopachrome isomerase activity
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010760 negative regulation of macrophage chemotaxis
GO:0019752 carboxylic acid metabolic process
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031982 vesicle
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034774 secretory granule lumen
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 innate immune response
GO:0048146 positive regulation of fibroblast proliferation
GO:0050178 phenylpyruvate tautomerase activity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070207 protein homotrimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090344 negative regulation of cell aging
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001398 Macrophage migration inhibitory factorFamilyFamily
IPR014347 Tautomerase/MIF superfamilyFamilyHomologous superfamily
IPR019829 Macrophage migration inhibitory factor, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01880 3,4-Dihydroxycinnamic AcidDrugbanksmall molecule
DB02728 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB07718 4-Hydroxyphenylpyruvic acidDrugbanksmall molecule
DB07888 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTERDrugbanksmall molecule
DB08333 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMEDrugbanksmall molecule
DB08334 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMEDrugbanksmall molecule
DB08335 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIMEDrugbanksmall molecule
DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDEDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MIF_HUMANB2L11_MOUSEUniProt18677096 details