Entity Details

Primary name HGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14210
EntryNameHGF_HUMAN
FullNameHepatocyte growth factor
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHGF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0000902 cell morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008083 growth factor activity
GO:0010507 negative regulation of autophagy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030212 hyaluronan metabolic process
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0031100 animal organ regeneration
GO:0031643 positive regulation of myelination
GO:0032715 negative regulation of interleukin-6 production
GO:0032733 positive regulation of interleukin-10 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044877 protein-containing complex binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050673 epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 positive regulation of neuron projection regeneration
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1900744 regulation of p38MAPK cascade
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902947 regulation of tau-protein kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003609 PAN/Apple domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR024174 Hepatocyte growth factor/Macrophage stimulatory proteinFamilyFamily
IPR027284 Hepatocyte growth factorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB02264 O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB03959 N,O6-Disulfo-GlucosamineDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule
DB12307 ForetinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HGF_HUMANMET_MOUSEIntAct18585357 details