Entity Details

Primary name ENPL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14625
EntryNameENPL_HUMAN
FullNameEndoplasmin
TaxID9606
Evidenceevidence at protein level
Length803
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesHSP90B1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002224 toll-like receptor signaling pathway
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006457 protein folding
GO:0006898 receptor-mediated endocytosis
GO:0015031 protein transport
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030496 midbody
GO:0030970 retrograde protein transport, ER to cytosol
GO:0031247 actin rod assembly
GO:0032991 protein-containing complex
GO:0033018 sarcoplasmic reticulum lumen
GO:0034975 protein folding in endoplasmic reticulum
GO:0034976 response to endoplasmic reticulum stress
GO:0036500 ATF6-mediated unfolded protein response
GO:0042470 melanosome
GO:0043066 negative regulation of apoptotic process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051082 unfolded protein binding
GO:0051208 sequestering of calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071318 cellular response to ATP
GO:0071682 endocytic vesicle lumen

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen
Melanosome
Sarcoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR001404 Heat shock protein Hsp90 familyFamilyFamily
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR019805 Heat shock protein Hsp90, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR020575 Heat shock protein Hsp90, N-terminalDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR037196 HSP90, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00615 RifabutinDrugbanksmall molecule
DB02103 2-ChlorodideoxyadenosineDrugbanksmall molecule
DB02424 GeldanamycinDrugbanksmall molecule
DB02935 DiglymeDrugbanksmall molecule
DB03719 N-Ethyl-5'-Carboxamido AdenosineDrugbanksmall molecule
DB03758 RadicicolDrugbanksmall molecule
DB08464 METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATEDrugbanksmall molecule
DB08465 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATEDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ENPL_HUMANMK13_MOUSEBioGRID19135240 details