Entity Details

Primary name PLAK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14923
EntryNamePLAK_HUMAN
FullNameJunction plakoglobin
TaxID9606
Evidenceevidence at protein level
Length745
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesJUP

GO terms

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GOName
GO:0001533 cornified envelope
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002159 desmosome assembly
GO:0003713 transcription coactivator activity
GO:0005198 structural molecule activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030018 Z disc
GO:0030057 desmosome
GO:0031424 keratinization
GO:0032993 protein-DNA complex
GO:0034332 adherens junction organization
GO:0035580 specific granule lumen
GO:0042127 regulation of cell population proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0044877 protein-containing complex binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050839 cell adhesion molecule binding
GO:0050982 detection of mechanical stimulus
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0071603 endothelial cell-cell adhesion
GO:0071665 gamma-catenin-TCF7L2 complex
GO:0071681 cellular response to indole-3-methanol
GO:0072659 protein localization to plasma membrane
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098609 cell-cell adhesion
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0106006 cytoskeletal protein-membrane anchor activity
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013284 Beta-cateninFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR030461 Junction plakoglobinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule