Entity Details

Primary name BRAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15056
EntryNameBRAF_HUMAN
FullNameSerine/threonine-protein kinase B-raf
TaxID9606
Evidenceevidence at protein level
Length766
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesBRAF

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010828 positive regulation of glucose transmembrane transport
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB05190 XL281Drugbanksmall molecule
DB05984 RAF-265Drugbanksmall molecule
DB06999 PLX-4720Drugbanksmall molecule
DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamideDrugbanksmall molecule
DB08553 (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB11718 EncorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule

Interactions

3 interactions