Entity Details

Primary name DESP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15924
EntryNameDESP_HUMAN
FullNameDesmoplakin
TaxID9606
Evidenceevidence at protein level
Length2871
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesDSP

GO terms

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GOName
GO:0001533 cornified envelope
GO:0002934 desmosome organization
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003723 RNA binding
GO:0005080 protein kinase C binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005916 fascia adherens
GO:0008544 epidermis development
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0018149 peptide cross-linking
GO:0030057 desmosome
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
GO:0034332 adherens junction organization
GO:0042060 wound healing
GO:0043312 neutrophil degranulation
GO:0043588 skin development
GO:0045104 intermediate filament cytoskeleton organization
GO:0045109 intermediate filament organization
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090136 epithelial cell-cell adhesion
GO:0097110 scaffold protein binding
GO:0098609 cell-cell adhesion
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0101003 ficolin-1-rich granule membrane
GO:0150105 protein localization to cell-cell junction

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001101 Plectin repeatRepeatRepeat
IPR001452 SH3 domainDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR028462 DesmoplakinFamilyFamily
IPR035915 Plakin repeat superfamilyFamilyHomologous superfamily
IPR041573 Desmoplakin, spectrin-like domainDomainDomain
IPR041615 Desmoplakin, SH3 domainDomainDomain
IPR043197 PlakinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule

Interactions

0 interactions

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