Entity Details

Primary name H2AX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16104
EntryNameH2AX_HUMAN
FullNameHistone H2AX
TaxID9606
Evidenceevidence at protein level
Length143
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesH2AX

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000724 double-strand break repair via homologous recombination
GO:0000786 nucleosome
GO:0000794 condensed nuclear chromosome
GO:0001673 male germ cell nucleus
GO:0001741 XY body
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005813 centrosome
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006334 nucleosome assembly
GO:0006342 chromatin silencing
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0010212 response to ionizing radiation
GO:0016032 viral process
GO:0016607 nuclear speck
GO:0019899 enzyme binding
GO:0021987 cerebral cortex development
GO:0035861 site of double-strand break
GO:0042393 histone binding
GO:0045739 positive regulation of DNA repair
GO:0046982 protein heterodimerization activity
GO:0051321 meiotic cell cycle
GO:0070062 extracellular exosome
GO:0071480 cellular response to gamma radiation
GO:0090398 cellular senescence
GO:0090734 site of DNA damage

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002119 Histone H2AFamilyFamily
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR009072 Histone-foldFamilyHomologous superfamily
IPR032454 Histone H2A, C-terminal domainDomainDomain
IPR032458 Histone H2A conserved siteSiteConserved site

Diseases

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Interactions

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