Entity Details

Primary name CBR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16152
EntryNameCBR1_HUMAN
FullNameCarbonyl reductase [NADPH] 1
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesCBR1

GO terms

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GOName
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005829 cytosol
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0017144 drug metabolic process
GO:0019371 cyclooxygenase pathway
GO:0030855 epithelial cell differentiation
GO:0042373 vitamin K metabolic process
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221 prostaglandin-E2 9-reductase activity
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00414 AcetohexamideDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01046 LubiprostoneDrugbanksmall molecule
DB01698 RutinDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03394 Heptaethylene glycolDrugbanksmall molecule
DB03556 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400Drugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04463 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)PhenolDrugbanksmall molecule
DB04844 TetrabenazineDrugbanksmall molecule
DB05197 SofalconeSwissprotsmall molecule
DB06263 AmrubicinDrugbanksmall molecule
DB09212 LoxoprofenDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB12161 DeutetrabenazineDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CBR1_HUMANMK13_MOUSEBioGRID19135240 details