Entity Details

Primary name NCK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16333
EntryNameNCK1_HUMAN
FullNameCytoplasmic protein NCK1
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesNCK1

GO terms

Show/Hide Table
GOName
GO:0000164 protein phosphatase type 1 complex
GO:0004860 protein kinase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007015 actin filament organization
GO:0007172 signal complex assembly
GO:0008093 cytoskeletal anchor activity
GO:0010976 positive regulation of neuron projection development
GO:0012506 vesicle membrane
GO:0019904 protein domain specific binding
GO:0030032 lamellipodium assembly
GO:0030159 signaling receptor complex adaptor activity
GO:0030334 regulation of cell migration
GO:0030674 protein-macromolecule adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0030971 receptor tyrosine kinase binding
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045296 cadherin binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046875 ephrin receptor binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
GO:0070262 peptidyl-serine dephosphorylation
GO:0071074 eukaryotic initiation factor eIF2 binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903676 positive regulation of cap-dependent translational initiation
GO:1903679 positive regulation of cap-independent translational initiation
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Endoplasmic reticulum
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR017304 Cytoplasmic protein NCKFamilyFamily
IPR028526 Cytoplasmic protein NCK1FamilyFamily
IPR035562 Nck1, SH3 domain 1DomainDomain
IPR035564 Nck1, SH3 domain 2DomainDomain
IPR035565 Nck1, SH3 domain 3DomainDomain
IPR035882 Nck1, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table