Entity Details

Primary name ITB1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP09055
EntryNameITB1_MOUSE
FullNameIntegrin beta-1
TaxID10090
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesItgb1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0001701 in utero embryonic development
GO:0001968 fibronectin binding
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006909 phagocytosis
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0008542 visual learning
GO:0010763 positive regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014704 intercalated disc
GO:0021943 formation of radial glial scaffolds
GO:0030175 filopodium
GO:0031175 neuron projection development
GO:0032587 ruffle membrane
GO:0032594 protein transport within lipid bilayer
GO:0034665 integrin alpha1-beta1 complex
GO:0034677 integrin alpha7-beta1 complex
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0048738 cardiac muscle tissue development
GO:0048813 dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0050839 cell adhesion molecule binding
GO:0055007 cardiac muscle cell differentiation
GO:0097386 glial cell projection
GO:0098639 collagen binding involved in cell-matrix adhesion
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:2000273 positive regulation of signaling receptor activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0005178 integrin binding
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010710 regulation of collagen catabolic process
GO:0016020 membrane
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030032 lamellipodium assembly
GO:0031589 cell-substrate adhesion
GO:0034113 heterotypic cell-cell adhesion
GO:0034674 integrin alpha5-beta1 complex
GO:0038023 signaling receptor activity
GO:0043236 laminin binding
GO:0045596 negative regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0046982 protein heterodimerization activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071711 basement membrane organization
GO:0098685 Schaffer collateral - CA1 synapse
GO:0150003 regulation of spontaneous synaptic transmission
GO:0150103 reactive gliosis
GO:1990782 protein tyrosine kinase binding
GO:0001669 acrosomal vesicle
GO:0001894 tissue homeostasis
GO:0003779 actin binding
GO:0005102 signaling receptor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016477 cell migration
GO:0023035 CD40 signaling pathway
GO:0034666 integrin alpha2-beta1 complex
GO:0034680 integrin alpha10-beta1 complex
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035748 myelin sheath abaxonal region
GO:0042383 sarcolemma
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043547 positive regulation of GTPase activity
GO:0045211 postsynaptic membrane
GO:0045214 sarcomere organization
GO:0045666 positive regulation of neuron differentiation
GO:0048675 axon extension
GO:0050901 leukocyte tethering or rolling
GO:0051393 alpha-actinin binding
GO:0051726 regulation of cell cycle
GO:0055037 recycling endosome
GO:0070830 bicellular tight junction assembly
GO:0090303 positive regulation of wound healing
GO:0099699 integral component of synaptic membrane
GO:1901979 regulation of inward rectifier potassium channel activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000811 negative regulation of anoikis
GO:0001708 cell fate specification
GO:0002020 protease binding
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0005518 collagen binding
GO:0005911 cell-cell junction
GO:0007159 leukocyte cell-cell adhesion
GO:0008285 negative regulation of cell population proliferation
GO:0008305 integrin complex
GO:0008354 germ cell migration
GO:0019900 kinase binding
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030056 hemidesmosome
GO:0030335 positive regulation of cell migration
GO:0031345 negative regulation of cell projection organization
GO:0031594 neuromuscular junction
GO:0031623 receptor internalization
GO:0033627 cell adhesion mediated by integrin
GO:0034667 integrin alpha3-beta1 complex
GO:0034679 integrin alpha9-beta1 complex
GO:0034681 integrin alpha11-beta1 complex
GO:0042470 melanosome
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0045807 positive regulation of endocytosis
GO:0046872 metal ion binding
GO:0051951 positive regulation of glutamate uptake involved in transmission of nerve impulse
GO:0097060 synaptic membrane

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cell surface
Melanosome
Recycling endosome

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027071 Integrin beta-1 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
ITB1_MOUSEVEGFB_MOUSEBioGRID, IntAct15102471 32325033 details
ITB1_MOUSENDKB_MOUSEIntAct15102471 details
ITB1_MOUSETNFC_MOUSEIntAct15102471 details
ITB1_MOUSECNOT1_MOUSEIntAct15102471 details
ITB1_MOUSEHGH1_MOUSEIntAct15102471 details
ITB1_MOUSETM158_MOUSEIntAct15102471 details
ITB1_MOUSETLN1_MOUSEBioGRID, IntAct21947080 30333137 details
ITB1_MOUSEFERM2_MOUSEBioGRID21947080 25808491 30333137 details
ITB1_MOUSETRAF6_MOUSEBioGRID25808491 details
ITB1_MOUSEGANAB_MOUSEBioGRID30333137 details
ITB1_MOUSEPLCG1_MOUSEBioGRID30333137 details
ITB1_MOUSEHUWE1_MOUSEBioGRID30333137 details
ITB1_MOUSECKAP5_MOUSEBioGRID30333137 details
ITB1_MOUSEUBP8_MOUSEBioGRID30333137 details
ITB1_MOUSEXPO1_MOUSEBioGRID30333137 details
ITB1_MOUSEUBR4_MOUSEBioGRID30333137 details
ITB1_MOUSEFLNA_MOUSEBioGRID30333137 details
ITB1_MOUSEPDC6I_MOUSEBioGRID30333137 details
ITB1_MOUSEMOV10_MOUSEBioGRID30333137 details
ITB1_MOUSEPECR_MOUSEBioGRID30333137 details
ITB1_MOUSEGCN1_MOUSEBioGRID30333137 details
ITB1_MOUSEEIF3B_MOUSEBioGRID30333137 details
ITB1_MOUSEPLEC_MOUSEBioGRID30333137 details
ITB1_MOUSEMA2C1_MOUSEBioGRID30333137 details
ITB1_MOUSESMC2_MOUSEBioGRID30333137 details
ITB1_MOUSEIQGA1_MOUSEBioGRID30333137 details
ITB1_MOUSEDHX36_MOUSEBioGRID30333137 details
ITB1_MOUSESP16H_MOUSEBioGRID30333137 details
ITB1_MOUSEUBP4_MOUSEBioGRID30333137 details
ITB1_MOUSEIF4G2_MOUSEBioGRID30333137 details
ITB1_MOUSEJUN_MOUSEBioGRID30333137 details
ITB1_MOUSEMA2B1_MOUSEBioGRID30333137 details
ITB1_MOUSESPT5H_MOUSEBioGRID30333137 details
ITB1_MOUSENUCL_MOUSEBioGRID30333137 details
ITB1_MOUSEFAS_MOUSEBioGRID30333137 details
ITB1_MOUSECBL_MOUSEBioGRID30333137 details
ITB1_MOUSEGDIA_MOUSEBioGRID30333137 details
ITB1_MOUSEUBP5_MOUSEBioGRID30333137 details
ITB1_MOUSEACTN4_MOUSEBioGRID30333137 details
ITB1_MOUSEIMB1_MOUSEBioGRID30333137 details
ITB1_MOUSEPRKDC_MOUSEBioGRID30333137 details
ITB1_MOUSEXDH_MOUSEBioGRID30333137 details
ITB1_MOUSEPSMD1_MOUSEBioGRID30333137 details
ITB1_MOUSEDDB1_MOUSEBioGRID30333137 details
ITB1_MOUSEMYH10_MOUSEBioGRID30333137 details
ITB1_MOUSEDIP2B_MOUSEBioGRID30333137 details
ITB1_MOUSEC1TM_MOUSEBioGRID30333137 details
ITB1_MOUSEPUR4_MOUSEBioGRID30333137 details
ITB1_MOUSEODO1_MOUSEBioGRID30333137 details
ITB1_MOUSEHS105_MOUSEBioGRID30333137 details
ITB1_MOUSEPCBP2_MOUSEBioGRID30333137 details
ITB1_MOUSEVINC_MOUSEBioGRID30333137 details
ITB1_MOUSEF120A_MOUSEBioGRID30333137 details
ITB1_MOUSESYVC_MOUSEBioGRID30333137 details
ITB1_MOUSETPR_MOUSEBioGRID30333137 details
ITB1_MOUSEKPBB_MOUSEBioGRID30333137 details
ITB1_MOUSESYIC_MOUSEBioGRID30333137 details
ITB1_MOUSETAOK3_MOUSEBioGRID30333137 details
ITB1_MOUSECPSM_MOUSEBioGRID30333137 details
ITB1_MOUSENCKPL_MOUSEBioGRID30333137 details
ITB1_MOUSEPREP_MOUSEBioGRID30333137 details
ITB1_MOUSESF3A1_MOUSEBioGRID30333137 details
ITB1_MOUSEEIF3C_MOUSEBioGRID30333137 details
ITB1_MOUSEMYH9_MOUSEBioGRID30333137 details
ITB1_MOUSEPRP8_MOUSEBioGRID30333137 details
ITB1_MOUSEDYHC1_MOUSEBioGRID30333137 details
ITB1_MOUSEIL3RB_MOUSEI2D20802515 details
ITB1_MOUSECCND1_MOUSEI2D21242975 details
ITB1_MOUSEWASL_MOUSEMINT21427700 details
ITB1_MOUSEDAB2_MOUSEUniProt15734730 details
ITB1_MOUSEEGLN_MOUSEMINT22940691 details
ITB1_MOUSEITA6_MOUSEBioGRID1833411 details
ITB1_MOUSENRK2_MOUSEBioGRID10613898 details
ITB1_MOUSEPTPRC_MOUSEBioGRID10906147 details
ITB1_MOUSECAD17_MOUSEBioGRID10906147 32325033 details
ITB1_MOUSEITA3_MOUSEBioGRID10939329 25808491 details
ITB1_MOUSESDC4_MOUSEBioGRID25202019 details
ITB1_MOUSEVGFR2_MOUSEBioGRID28973887 details
ITB1_MOUSERELN_MOUSEBioGRID10939329 details