Entity Details

Primary name KPCA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17252
EntryNameKPCA_HUMAN
FullNameProtein kinase C alpha type
TaxID9606
Evidenceevidence at protein level
Length672
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCA

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002159 desmosome assembly
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007077 mitotic nuclear membrane disassembly
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0008270 zinc ion binding
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031966 mitochondrial membrane
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035403 histone kinase activity (H3-T6 specific)
GO:0035408 histone H3-T6 phosphorylation
GO:0035556 intracellular signal transduction
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0038128 ERBB2 signaling pathway
GO:0043488 regulation of mRNA stability
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045651 positive regulation of macrophage differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0045931 positive regulation of mitotic cell cycle
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0090330 regulation of platelet aggregation
GO:0097190 apoptotic signaling pathway
GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000707 positive regulation of dense core granule biogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014375 Protein kinase C, alpha/beta/gamma typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR034663 Classical Protein Kinase C alpha, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00144 Phosphatidyl serineDrugbanksmall molecule
DB00163 Vitamin EDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB05013 Ingenol mebutateDrugbanksmall molecule
DB06451 AprinocarsenDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06641 PerifosineDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB11752 Bryostatin 1Drugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
KPCA_HUMANJAK2_MOUSEMINT17290288 details
KPCA_HUMANMARCS_MOUSEBioGRID7588787 details