Entity Details

Primary name TAL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17542
EntryNameTAL1_HUMAN
FullNameT-cell acute lymphocytic leukemia protein 1
TaxID9606
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesTAL1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0007626 locomotory behavior
GO:0019899 enzyme binding
GO:0021527 spinal cord association neuron differentiation
GO:0030097 hemopoiesis
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030221 basophil differentiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0035162 embryonic hemopoiesis
GO:0035855 megakaryocyte development
GO:0042127 regulation of cell population proliferation
GO:0042826 histone deacetylase binding
GO:0043249 erythrocyte maturation
GO:0045165 cell fate commitment
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045799 positive regulation of chromatin assembly or disassembly
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0051781 positive regulation of cell division
GO:0060018 astrocyte fate commitment
GO:0060216 definitive hemopoiesis
GO:0060217 hemangioblast cell differentiation
GO:0060218 hematopoietic stem cell differentiation
GO:0060375 regulation of mast cell differentiation
GO:0070888 E-box binding
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:2000036 regulation of stem cell population maintenance

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR040238 Helix-loop-helix protein TAL-likeFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TAL1_HUMANRBTN2_MOUSEIntAct7568177 details