Entity Details

Primary name KAPCA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17612
EntryNameKAPCA_HUMAN
FullNamecAMP-dependent protein kinase catalytic subunit alpha
TaxID9606
Evidenceevidence at protein level
Length351
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPRKACA

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000287 magnesium ion binding
GO:0001669 acrosomal vesicle
GO:0001707 mesoderm formation
GO:0001843 neural tube closure
GO:0002027 regulation of heart rate
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005952 cAMP-dependent protein kinase complex
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007268 chemical synaptic transmission
GO:0007596 blood coagulation
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010737 protein kinase A signaling
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030145 manganese ion binding
GO:0031588 nucleotide-activated protein kinase complex
GO:0031594 neuromuscular junction
GO:0031625 ubiquitin protein ligase binding
GO:0034199 activation of protein kinase A activity
GO:0034237 protein kinase A regulatory subunit binding
GO:0034380 high-density lipoprotein particle assembly
GO:0034605 cellular response to heat
GO:0034704 calcium channel complex
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0036126 sperm flagellum
GO:0043197 dendritic spine
GO:0043393 regulation of protein binding
GO:0044853 plasma membrane raft
GO:0045667 regulation of osteoblast differentiation
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0048240 sperm capacitation
GO:0048471 perinuclear region of cytoplasm
GO:0050804 modulation of chemical synaptic transmission
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070062 extracellular exosome
GO:0070613 regulation of protein processing
GO:0071333 cellular response to glucose stimulus
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071872 cellular response to epinephrine stimulus
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0097225 sperm midpiece
GO:0097546 ciliary base
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:1903779 regulation of cardiac conduction
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044109 cAMP-dependent protein kinase catalytic subunitFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01919 PentanalDrugbanksmall molecule
DB01940 Balanol Analog 2Drugbanksmall molecule
DB02155 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoateDrugbanksmall molecule
DB02482 PhosphonothreonineDrugbanksmall molecule
DB02611 Balanol Analog 1Drugbanksmall molecule
DB03374 3,5-DiiodotyrosineDrugbanksmall molecule
DB04098 BalanolDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB04707 HydroxyfasudilDrugbanksmall molecule
DB06959 (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamineDrugbanksmall molecule
DB06977 (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamineDrugbanksmall molecule
DB07107 (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINEDrugbanksmall molecule
DB07124 (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule
DB07204 (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINEDrugbanksmall molecule
DB07235 N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDEDrugbanksmall molecule
DB07458 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dioneDrugbanksmall molecule
DB07583 (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINEDrugbanksmall molecule
DB07854 N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDrugbanksmall molecule
DB07855 (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDrugbanksmall molecule
DB07856 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINEDrugbanksmall molecule
DB07857 (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineDrugbanksmall molecule
DB07858 (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineDrugbanksmall molecule
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDrugbanksmall molecule
DB07860 (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINEDrugbanksmall molecule
DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDrugbanksmall molecule
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDrugbanksmall molecule
DB07995 H-89Drugbanksmall molecule
DB07996 5-(2-methylpiperazine-1-sulfonyl)isoquinolineDrugbanksmall molecule
DB07997 N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDEDrugbanksmall molecule
DB08070 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDrugbanksmall molecule
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule
DB08113 3-pyridin-4-yl-1H-indazoleDrugbanksmall molecule
DB08114 5-benzyl-1,3-thiazol-2-amineDrugbanksmall molecule
DB08148 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDrugbanksmall molecule
DB08149 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDrugbanksmall molecule
DB08150 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminiumDrugbanksmall molecule
DB08162 FasudilDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08568 A-674563Drugbanksmall molecule
DB08569 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLEDrugbanksmall molecule
DB08756 Y-27632Drugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule