Entity Details

Primary name LEG3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17931
EntryNameLEG3_HUMAN
FullNameGalectin-3
TaxID9606
Evidenceevidence at protein level
Length250
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesLGALS3

GO terms

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GOName
GO:0001772 immunological synapse
GO:0002548 monocyte chemotaxis
GO:0003723 RNA binding
GO:0004864 protein phosphatase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0009986 cell surface
GO:0016020 membrane
GO:0019863 IgE binding
GO:0019903 protein phosphatase binding
GO:0030246 carbohydrate binding
GO:0030593 neutrophil chemotaxis
GO:0030667 secretory granule membrane
GO:0030855 epithelial cell differentiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031640 killing of cells of other organism
GO:0042056 chemoattractant activity
GO:0042129 regulation of T cell proliferation
GO:0043236 laminin binding
GO:0043312 neutrophil degranulation
GO:0044216 obsolete other organism cell
GO:0045087 innate immune response
GO:0045637 regulation of myeloid cell differentiation
GO:0045806 negative regulation of endocytosis
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050918 positive chemotaxis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070232 regulation of T cell apoptotic process
GO:0070492 oligosaccharide binding
GO:0071674 mononuclear cell migration
GO:0071677 positive regulation of mononuclear cell migration
GO:0090280 positive regulation of calcium ion import
GO:0101003 ficolin-1-rich granule membrane
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903614 negative regulation of protein tyrosine phosphatase activity
GO:2000521 negative regulation of immunological synapse formation
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001079 Galectin, carbohydrate recognition domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR015534 Galectin-3FamilyFamily
IPR044156 Galectin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01827 2,3,5,6-Tetrafluoro-4-Methoxy-BenzamideDrugbanksmall molecule
DB04465 LactoseDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
LEG3_HUMANPDC6I_MOUSEDIP19706535 details