Entity Details

Primary name IBP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17936
EntryNameIBP3_HUMAN
FullNameInsulin-like growth factor-binding protein 3
TaxID9606
Evidenceevidence at protein level
Length291
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesIGFBP3

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001933 negative regulation of protein phosphorylation
GO:0001968 fibronectin binding
GO:0005520 insulin-like growth factor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005788 endoplasmic reticulum lumen
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008160 protein tyrosine phosphatase activator activity
GO:0008285 negative regulation of cell population proliferation
GO:0009968 negative regulation of signal transduction
GO:0010906 regulation of glucose metabolic process
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016942 insulin-like growth factor binding protein complex
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0042567 insulin-like growth factor ternary complex
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044342 type B pancreatic cell proliferation
GO:0045663 positive regulation of myoblast differentiation
GO:0046872 metal ion binding
GO:0048662 negative regulation of smooth muscle cell proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR012211 Insulin-like growth factor binding protein 3FamilyFamily
IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved siteSiteConserved site
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordataFamilyFamily
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00523 AlitretinoinDrugbanksmall molecule
DB01277 MecaserminDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
IBP3_HUMANLTBP1_MOUSEBioGRID12962157 details
IBP3_HUMANIGF2_MOUSEBioGRID12962157 details