Entity Details

Primary name ATF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18848
EntryNameATF4_HUMAN
FullNameCyclic AMP-dependent transcription factor ATF-4
TaxID9606
Evidenceevidence at protein level
Length351
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesATF4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006874 cellular calcium ion homeostasis
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0008022 protein C-terminus binding
GO:0008140 cAMP response element binding protein binding
GO:0009636 response to toxic substance
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0030182 neuron differentiation
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031667 response to nutrient levels
GO:0032057 negative regulation of translational initiation in response to stress
GO:0032590 dendrite membrane
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034399 nuclear periphery
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035162 embryonic hemopoiesis
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042789 mRNA transcription by RNA polymerase II
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0043522 leucine zipper domain binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045667 regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048167 regulation of synaptic plasticity
GO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070169 positive regulation of biomineral tissue development
GO:0070309 lens fiber cell morphogenesis
GO:0070982 L-asparagine metabolic process
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140467 integrated stress response signaling
GO:0140468 HRI-mediated signaling
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903351 cellular response to dopamine
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1990037 Lewy body core
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990589 ATF4-CREB1 transcription factor complex
GO:1990590 ATF1-ATF4 transcription factor complex
GO:1990617 CHOP-ATF4 complex
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000120 positive regulation of sodium-dependent phosphate transport

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029811 cAMP-dependent transcription factor ATF-4FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00852 PseudoephedrineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ATF4_HUMANCEBPB_MOUSEBioGRID, MINT11018027 details
ATF4_HUMANDAPK3_MOUSEUniProt9488481 details