Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Genes

HK1

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GO	Name
GO:0001678	cellular glucose homeostasis
GO:0002720	positive regulation of cytokine production involved in immune response
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0006002	fructose 6-phosphate metabolic process
GO:0006013	mannose metabolic process
GO:0006096	glycolytic process
GO:0006954	inflammatory response
GO:0008865	fructokinase activity
GO:0019158	mannokinase activity
GO:0032731	positive regulation of interleukin-1 beta production
GO:0042834	peptidoglycan binding
GO:0045087	innate immune response
GO:0045121	membrane raft
GO:0046835	carbohydrate phosphorylation
GO:0047931	glucosamine kinase activity
GO:0051156	glucose 6-phosphate metabolic process
GO:0061621	canonical glycolysis
GO:0072655	establishment of protein localization to mitochondrion
GO:0072656	maintenance of protein location in mitochondrion

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

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Domain	Name	Category	Type
IPR001312	Hexokinase	Family	Family
IPR019807	Hexokinase, binding site	Site	Binding site
IPR022672	Hexokinase, N-terminal	Domain	Domain
IPR022673	Hexokinase, C-terminal	Domain	Domain
IPR043129	ATPase, nucleotide binding domain	Family	Homologous superfamily

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Drug	Name	Source	Type
DB01914	D-glucose	Swissprot	small molecule
DB02007	alpha-D-glucose 6-phosphate	Drugbank	small molecule
DB02379	Beta-D-Glucose	Drugbank	small molecule
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Drugbank	small molecule
DB06266	Lonidamine	Drugbank	small molecule
DB09341	Dextrose, unspecified form	Swissprot	small molecule
DB09502	Fludeoxyglucose (18F)	Swissprot	small molecule

1 interaction

Interactor	Partner	Sources	Publications	Link
HXK1_HUMAN	SRC_MOUSE	IntAct	28054552	details