Entity Details

Primary name TNR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19438
EntryNameTNR1A_HUMAN
FullNameTumor necrosis factor receptor superfamily member 1A
TaxID9606
Evidenceevidence at protein level
Length455
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF1A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003332 negative regulation of extracellular matrix constituent secretion
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006693 prostaglandin metabolic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043120 tumor necrosis factor binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
GO:0071550 death-inducing signaling complex assembly
GO:0072659 protein localization to plasma membrane
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:1903140 regulation of establishment of endothelial barrier
GO:2000304 positive regulation of ceramide biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane
Secreted

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020419 Tumour necrosis factor receptor 1AFamilyFamily
IPR033993 Tumor necrosis factor receptor 1A, N-terminalDomainDomain
IPR033994 Tumor necrosis factor receptor 1A, death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03507 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-OneDrugbanksmall molecule
DB11626 TasonerminDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TNR1A_HUMANTRAF1_MOUSEBioGRID11035039 details