Entity Details

Primary name E2AK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19525
EntryNameE2AK2_HUMAN
FullNameInterferon-induced, double-stranded RNA-activated protein kinase
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK2

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001819 positive regulation of cytokine production
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0009615 response to virus
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019888 protein phosphatase regulator activity
GO:0030683 mitigation of host immune response by virus
GO:0032722 positive regulation of chemokine production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033689 negative regulation of osteoblast proliferation
GO:0034198 cellular response to amino acid starvation
GO:0035455 response to interferon-alpha
GO:0042802 identical protein binding
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900225 regulation of NLRP3 inflammasome complex assembly
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1902033 regulation of hematopoietic stem cell proliferation
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044452 EIF2AK2, first double-stranded RNA binding domainDomainDomain
IPR044453 EIF2AK2, second double-stranded RNA binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
E2AK2_HUMANJAK2_MOUSEBioGRID17290288 details
E2AK2_HUMANTRAF3_MOUSEDIP16306936 details