Entity Details

Primary name RXRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19793
EntryNameRXRA_HUMAN
FullNameRetinoic acid receptor RXR-alpha
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesRXRA

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001972 retinoic acid binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008203 cholesterol metabolic process
GO:0008270 zinc ion binding
GO:0015721 bile acid and bile salt transport
GO:0016922 nuclear receptor binding
GO:0019048 modulation by virus of host process
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030851 granulocyte differentiation
GO:0032526 response to retinoic acid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042277 peptide binding
GO:0042802 identical protein binding
GO:0042809 vitamin D receptor binding
GO:0043235 receptor complex
GO:0043565 sequence-specific DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048384 retinoic acid receptor signaling pathway
GO:0048856 anatomical structure development
GO:0050692 DNA binding domain binding
GO:0050693 LBD domain binding
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000003 Retinoid X receptor/HNF4FamilyFamily
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021780 Nuclear/hormone receptor activator site AF-1DomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00210 AdapaleneDrugbanksmall molecule
DB00307 BexaroteneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00749 EtodolacDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01436 AlfacalcidolDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule
DB04224 Oleic AcidDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB05956 EVT-101Drugbanksmall molecule
DB07557 3,20-PregnanedioneDrugbanksmall molecule
DB07863 2-chloro-5-nitro-N-phenylbenzamideDrugbanksmall molecule
DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONEDrugbanksmall molecule
DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDrugbanksmall molecule
DB08601 TributyltinDrugbanksmall molecule