Entity Details

Primary name NFKB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19838
EntryNameNFKB1_HUMAN
FullNameNuclear factor NF-kappa-B p105 subunit
TaxID9606
Evidenceevidence at protein level
Length968
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNFKB1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0019899 enzyme binding
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032375 negative regulation of cholesterol transport
GO:0032481 positive regulation of type I interferon production
GO:0032695 negative regulation of interleukin-12 production
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen
GO:0035994 response to muscle stretch
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042802 identical protein binding
GO:0042805 actinin binding
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071359 cellular response to dsRNA
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1904385 cellular response to angiotensin
GO:2000630 positive regulation of miRNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000451 NF-kappa-B/DorsalFamilyFamily
IPR000488 Death domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR030492 Rel homology domain, conserved siteSiteConserved site
IPR030503 Nuclear factor NF-kappa-B, p105 subunitFamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR033926 NFkappaB IPT domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00843 DonepezilDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01411 PranlukastDrugbanksmall molecule
DB05212 HE3286Drugbanksmall molecule
DB05451 P54Drugbanksmall molecule
DB05464 NOX-700Drugbanksmall molecule
DB05471 SGN-30Drugbankbiotech
DB05487 CustirsenDrugbanksmall molecule
DB05559 NF-kappaB DecoyDrugbanksmall molecule
DB05767 AndrographolideDrugbanksmall molecule
DB08814 TriflusalDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14059 SC-236Drugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink