Entity Details

Primary name NCF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19878
EntryNameNCF2_HUMAN
FullNameNeutrophil cytosol factor 2
TaxID9606
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNCF2

GO terms

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GOName
GO:0001669 acrosomal vesicle
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005829 cytosol
GO:0006801 superoxide metabolic process
GO:0006909 phagocytosis
GO:0006968 cellular defense response
GO:0008022 protein C-terminus binding
GO:0009055 electron transfer activity
GO:0016020 membrane
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0031267 small GTPase binding
GO:0032010 phagolysosome
GO:0034599 cellular response to oxidative stress
GO:0042554 superoxide anion generation
GO:0043020 NADPH oxidase complex
GO:0045087 innate immune response
GO:0045454 cell redox homeostasis
GO:0045730 respiratory burst
GO:0048010 vascular endothelial growth factor receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR034885 Neutrophil cytosol factor 2, PB1 domainDomainDomain
IPR034889 Neutrophil cytosol factor 2FamilyFamily
IPR035546 Neutrophil cytosol factor 2, SH3 domain 1DomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NCF2_HUMANVAV_MOUSEDIP22203994 details