Entity Details

Primary name CCNA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20248
EntryNameCCNA2_HUMAN
FullNameCyclin-A2
TaxID9606
Evidenceevidence at protein level
Length432
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCCNA2

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006275 regulation of DNA replication
GO:0007265 Ras protein signal transduction
GO:0016032 viral process
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0016572 histone phosphorylation
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031100 animal organ regeneration
GO:0033762 response to glucagon
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0044320 cellular response to leptin stimulus
GO:0044772 mitotic cell cycle phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051301 cell division
GO:0071314 cellular response to cocaine
GO:0071373 cellular response to luteinizing hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071732 cellular response to nitric oxide
GO:0090102 cochlea development
GO:0097124 cyclin A2-CDK2 complex
GO:1990314 cellular response to insulin-like growth factor stimulus

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004367 Cyclin, C-terminal domainDomainDomain
IPR006671 Cyclin, N-terminalDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR032447 Cyclin-A, N-terminalDomainDomain
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily
IPR039361 CyclinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02091 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-YlamineDrugbanksmall molecule
DB02407 6-O-Cyclohexylmethyl GuanineDrugbanksmall molecule
DB02833 [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-AmineDrugbanksmall molecule
DB02915 4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamineDrugbanksmall molecule
DB06844 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDEDrugbanksmall molecule
DB06944 N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamideDrugbanksmall molecule
DB06948 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINEDrugbanksmall molecule
DB07126 O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINEDrugbanksmall molecule
DB07137 (2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamideDrugbanksmall molecule
DB07164 N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amineDrugbanksmall molecule
DB07203 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINEDrugbanksmall molecule
DB07471 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDEDrugbanksmall molecule
DB07533 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDEDrugbanksmall molecule
DB07534 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDEDrugbanksmall molecule
DB07538 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDEDrugbanksmall molecule
DB07539 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACIDDrugbanksmall molecule
DB07562 N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINEDrugbanksmall molecule
DB07688 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDEDrugbanksmall molecule
DB07852 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDDrugbanksmall molecule
DB08178 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineDrugbanksmall molecule
DB08182 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineDrugbanksmall molecule
DB08218 HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUMDrugbanksmall molecule
DB08219 4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amineDrugbanksmall molecule
DB08233 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINEDrugbanksmall molecule
DB08241 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDEDrugbanksmall molecule
DB08248 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDEDrugbanksmall molecule
DB08285 (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olDrugbanksmall molecule
DB08309 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OLDrugbanksmall molecule
DB08355 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acidDrugbanksmall molecule
DB08463 (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-olDrugbanksmall molecule
DB08527 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDEDrugbanksmall molecule
DB08572 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDEDrugbanksmall molecule
DB08694 Variolin BDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CCNA2_HUMANSAMH1_MOUSEBioGRID24623419 details