Entity Details

Primary name HNF1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20823
EntryNameHNF1A_HUMAN
FullNameHepatocyte nuclear factor 1-alpha
TaxID9606
Evidenceevidence at protein level
Length631
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesHNF1A

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030073 insulin secretion
GO:0031016 pancreas development
GO:0032991 protein-containing complex
GO:0035623 renal glucose absorption
GO:0042593 glucose homeostasis
GO:0042803 protein homodimerization activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046323 glucose import
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminalDomainDomain
IPR006898 Hepatocyte nuclear factor 1, alpha isoform C-terminalDomainDomain
IPR006899 Hepatocyte nuclear factor 1, N-terminalDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR023219 Hepatocyte nuclear factor 1, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039066 Hepatocyte nuclear factor 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04419 D-norleucineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HNF1A_HUMANSP7_MOUSEDIP18458345 details