Entity Details

Primary name RASA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20936
EntryNameRASA1_HUMAN
FullNameRas GTPase-activating protein 1
TaxID9606
Evidenceevidence at protein level
Length1047
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesRASA1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000281 mitotic cytokinesis
GO:0001570 vasculogenesis
GO:0001726 ruffle
GO:0001784 phosphotyrosine residue binding
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005096 GTPase activator activity
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0019870 potassium channel inhibitor activity
GO:0030833 regulation of actin filament polymerization
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0051020 GTPase binding
GO:0051252 regulation of RNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR028554 Ras GTPase-activating protein 1FamilyFamily
IPR035652 RasGAP, SH3 domainDomainDomain
IPR035841 Ras GTPase-activating protein 1, N-terminal SH2 domainDomainDomain
IPR035842 Ras GTPase-activating protein 1, C-terminal SH2 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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Interactions

4 interactions