Entity Details

Primary name TAF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21675
EntryNameTAF1_HUMAN
FullNameTranscription initiation factor TFIID subunit 1
TaxID9606
Evidenceevidence at protein level
Length1872
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesTAF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0000785 chromatin
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001181 RNA polymerase I general transcription initiation factor activity
GO:0002039 p53 binding
GO:0004402 histone acetyltransferase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005669 transcription factor TFIID complex
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0016032 viral process
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0016301 kinase activity
GO:0017025 TBP-class protein binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030901 midbrain development
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034644 cellular response to UV
GO:0036369 transcription factor catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0050821 protein stabilization
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
GO:0061631 ubiquitin conjugating enzyme activity
GO:0070577 lysine-acetylated histone binding
GO:0071318 cellular response to ATP
GO:0071339 MLL1 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140416 transcription regulator inhibitor activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1905524 negative regulation of protein autoubiquitination
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000825 positive regulation of androgen receptor activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001487 BromodomainDomainDomain
IPR009067 TAFII-230 TBP-bindingDomainDomain
IPR011177 Transcription initiation factor TFIID subunit 1, animalFamilyFamily
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR022591 Transcription initiation factor TFIID subunit 1, domain of unknown functionDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR036741 TAFII-230 TBP-binding domain superfamilyFamilyHomologous superfamily
IPR040240 Transcription initiation factor TFIID subunit 1FamilyFamily
IPR041670 Zinc knuckleDomainDomain

Diseases

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Interactions

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InteractorPartnerSourcesPublicationsLink